ChloroquineV1, Main, Exploration, bibRecord, 000C26

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.

Identifieur interne : 000C26 ( Main/Exploration ); précédent : 000C25; suivant : 000C27

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.

Auteurs : Joanna Kopecka [Italie] ; Iris C. Salaroglio [Italie] ; Luisella Righi [Italie] ; Roberta Libener [Italie] ; Sara Orecchia [Italie] ; Federica Grosso [Italie] ; Vladan Milosevic [Italie] ; Preeta Ananthanarayanan [Italie] ; Luisa Ricci [Italie] ; Enrica Capelletto [Italie] ; Monica Pradotto [Italie] ; Francesca Napoli [Italie] ; Massimo Di Maio [Italie] ; Silvia Novello [Italie] ; Menachem Rubinstein [Israël] ; Giorgio V. Scagliotti [Italie] ; Chiara Riganti [Italie]

Source :

Lung cancer (Amsterdam, Netherlands) [ 1872-8332 ] ; 2018.

RBID : pubmed:29748013

Descripteurs français

English descriptors

KwdEn :
- Adaptor Proteins, Signal Transducing (genetics), Adaptor Proteins, Signal Transducing (metabolism), Antineoplastic Agents (therapeutic use), Apoptosis, CCAAT-Enhancer-Binding Protein-beta (genetics), CCAAT-Enhancer-Binding Protein-beta (metabolism), CD8-Positive T-Lymphocytes (immunology), Cisplatin (therapeutic use), Dendritic Cells (immunology), Drug Resistance, Neoplasm (genetics), Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (genetics), Lung Neoplasms (mortality), Lymphocyte Activation, Mesothelioma (drug therapy), Mesothelioma (genetics), Mesothelioma (mortality), Oligopeptides (pharmacology), Pleural Neoplasms (drug therapy), Pleural Neoplasms (mortality), Prognosis, Proteolysis, Survival Analysis, Tumor Cells, Cultured, Ubiquitination.
MESH :
- chemical , genetics : Adaptor Proteins, Signal Transducing, CCAAT-Enhancer-Binding Protein-beta.
- chemical , metabolism : Adaptor Proteins, Signal Transducing, CCAAT-Enhancer-Binding Protein-beta.
- chemical , pharmacology : Oligopeptides.
- chemical , therapeutic use : Antineoplastic Agents, Cisplatin.
- drug therapy : Lung Neoplasms, Mesothelioma, Pleural Neoplasms.
- genetics : Drug Resistance, Neoplasm, Lung Neoplasms, Mesothelioma.
- immunology : CD8-Positive T-Lymphocytes, Dendritic Cells.
- mortality : Lung Neoplasms, Mesothelioma, Pleural Neoplasms.
- Apoptosis, Humans, Lymphocyte Activation, Prognosis, Proteolysis, Survival Analysis, Tumor Cells, Cultured, Ubiquitination.

Abstract

Cisplatin-based chemotherapy is moderately active in malignant pleural mesothelioma (MPM) due to intrinsic drug resistance and to low immunogenicity of MPM cells. CAAT/enhancer binding protein (C/EBP)-β LIP is a pro-apoptotic and chemosensitizing transcription factor activated in response to endoplasmic reticulum (ER) stress.

DOI: 10.1016/j.lungcan.2018.03.022
PubMed: 29748013

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.</title>
<author><name sortKey="Kopecka, Joanna" sort="Kopecka, Joanna" uniqKey="Kopecka J" first="Joanna" last="Kopecka">Joanna Kopecka</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: joanna.kopecka@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Salaroglio, Iris C" sort="Salaroglio, Iris C" uniqKey="Salaroglio I" first="Iris C" last="Salaroglio">Iris C. Salaroglio</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: irischiara.salaroglio@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Righi, Luisella" sort="Righi, Luisella" uniqKey="Righi L" first="Luisella" last="Righi">Luisella Righi</name>
<affiliation wicri:level="1"><nlm:affiliation>Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Regione Gonzole 10, 10043, Orbassano, Italy. Electronic address: luisella.righi@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Regione Gonzole 10, 10043, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Libener, Roberta" sort="Libener, Roberta" uniqKey="Libener R" first="Roberta" last="Libener">Roberta Libener</name>
<affiliation wicri:level="1"><nlm:affiliation>Pathology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria, Italy. Electronic address: rlibener@ospedale.al.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Pathology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria</wicri:regionArea>
<wicri:noRegion>Alessandria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Orecchia, Sara" sort="Orecchia, Sara" uniqKey="Orecchia S" first="Sara" last="Orecchia">Sara Orecchia</name>
<affiliation wicri:level="1"><nlm:affiliation>Pathology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria, Italy. Electronic address: sorecchia@ospedale.al.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Pathology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria</wicri:regionArea>
<wicri:noRegion>Alessandria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grosso, Federica" sort="Grosso, Federica" uniqKey="Grosso F" first="Federica" last="Grosso">Federica Grosso</name>
<affiliation wicri:level="1"><nlm:affiliation>Oncology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria, Italy. Electronic address: fgrosso@ospedale.al.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Oncology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria</wicri:regionArea>
<wicri:noRegion>Alessandria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Milosevic, Vladan" sort="Milosevic, Vladan" uniqKey="Milosevic V" first="Vladan" last="Milosevic">Vladan Milosevic</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: vladan.milosevic@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ananthanarayanan, Preeta" sort="Ananthanarayanan, Preeta" uniqKey="Ananthanarayanan P" first="Preeta" last="Ananthanarayanan">Preeta Ananthanarayanan</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: preeta.ananthanarayanan@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ricci, Luisa" sort="Ricci, Luisa" uniqKey="Ricci L" first="Luisa" last="Ricci">Luisa Ricci</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: luisa.ricci@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Capelletto, Enrica" sort="Capelletto, Enrica" uniqKey="Capelletto E" first="Enrica" last="Capelletto">Enrica Capelletto</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano, Italy. Electronic address: enrica.capelletto@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pradotto, Monica" sort="Pradotto, Monica" uniqKey="Pradotto M" first="Monica" last="Pradotto">Monica Pradotto</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano, Italy. Electronic address: monica.pradotto@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Napoli, Francesca" sort="Napoli, Francesca" uniqKey="Napoli F" first="Francesca" last="Napoli">Francesca Napoli</name>
<affiliation wicri:level="1"><nlm:affiliation>Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Regione Gonzole 10, 10043, Orbassano, Italy. Electronic address: francesca.napoli@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Regione Gonzole 10, 10043, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Di Maio, Massimo" sort="Di Maio, Massimo" uniqKey="Di Maio M" first="Massimo" last="Di Maio">Massimo Di Maio</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Division, Department of Oncology at Mauriziano Hospital, Largo Filippo Turati 62, 10128, University of Torino, Italy. Electronic address: massimo.dimaio@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Medical Oncology Division, Department of Oncology at Mauriziano Hospital, Largo Filippo Turati 62, 10128, University of Torino</wicri:regionArea>
<wicri:noRegion>University of Torino</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novello, Silvia" sort="Novello, Silvia" uniqKey="Novello S" first="Silvia" last="Novello">Silvia Novello</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano, Italy. Electronic address: silvia.novello@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rubinstein, Menachem" sort="Rubinstein, Menachem" uniqKey="Rubinstein M" first="Menachem" last="Rubinstein">Menachem Rubinstein</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, The Weizmann Institute of Science, Herzl Street 234, 76100, Rehovot, Israel. Electronic address: menachem.rubinstein@weizmann.ac.il.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Molecular Genetics, The Weizmann Institute of Science, Herzl Street 234, 76100, Rehovot</wicri:regionArea>
<wicri:noRegion>Rehovot</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scagliotti, Giorgio V" sort="Scagliotti, Giorgio V" uniqKey="Scagliotti G" first="Giorgio V" last="Scagliotti">Giorgio V. Scagliotti</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano, Italy. Electronic address: giorgio.scagliotti@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Riganti, Chiara" sort="Riganti, Chiara" uniqKey="Riganti C" first="Chiara" last="Riganti">Chiara Riganti</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: chiara.riganti@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29748013</idno>
<idno type="pmid">29748013</idno>
<idno type="doi">10.1016/j.lungcan.2018.03.022</idno>
<idno type="wicri:Area/PubMed/Corpus">000109</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000109</idno>
<idno type="wicri:Area/PubMed/Curation">000109</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000109</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000099</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000099</idno>
<idno type="wicri:Area/Ncbi/Merge">000444</idno>
<idno type="wicri:Area/Ncbi/Curation">000444</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000444</idno>
<idno type="wicri:Area/Main/Merge">000C26</idno>
<idno type="wicri:Area/Main/Curation">000C26</idno>
<idno type="wicri:Area/Main/Exploration">000C26</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.</title>
<author><name sortKey="Kopecka, Joanna" sort="Kopecka, Joanna" uniqKey="Kopecka J" first="Joanna" last="Kopecka">Joanna Kopecka</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: joanna.kopecka@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Salaroglio, Iris C" sort="Salaroglio, Iris C" uniqKey="Salaroglio I" first="Iris C" last="Salaroglio">Iris C. Salaroglio</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: irischiara.salaroglio@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Righi, Luisella" sort="Righi, Luisella" uniqKey="Righi L" first="Luisella" last="Righi">Luisella Righi</name>
<affiliation wicri:level="1"><nlm:affiliation>Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Regione Gonzole 10, 10043, Orbassano, Italy. Electronic address: luisella.righi@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Regione Gonzole 10, 10043, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Libener, Roberta" sort="Libener, Roberta" uniqKey="Libener R" first="Roberta" last="Libener">Roberta Libener</name>
<affiliation wicri:level="1"><nlm:affiliation>Pathology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria, Italy. Electronic address: rlibener@ospedale.al.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Pathology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria</wicri:regionArea>
<wicri:noRegion>Alessandria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Orecchia, Sara" sort="Orecchia, Sara" uniqKey="Orecchia S" first="Sara" last="Orecchia">Sara Orecchia</name>
<affiliation wicri:level="1"><nlm:affiliation>Pathology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria, Italy. Electronic address: sorecchia@ospedale.al.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Pathology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria</wicri:regionArea>
<wicri:noRegion>Alessandria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grosso, Federica" sort="Grosso, Federica" uniqKey="Grosso F" first="Federica" last="Grosso">Federica Grosso</name>
<affiliation wicri:level="1"><nlm:affiliation>Oncology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria, Italy. Electronic address: fgrosso@ospedale.al.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Oncology Division, S. Antonio and Biagio Hospital, Spalto Marengo, 15121, Alessandria</wicri:regionArea>
<wicri:noRegion>Alessandria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Milosevic, Vladan" sort="Milosevic, Vladan" uniqKey="Milosevic V" first="Vladan" last="Milosevic">Vladan Milosevic</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: vladan.milosevic@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ananthanarayanan, Preeta" sort="Ananthanarayanan, Preeta" uniqKey="Ananthanarayanan P" first="Preeta" last="Ananthanarayanan">Preeta Ananthanarayanan</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: preeta.ananthanarayanan@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ricci, Luisa" sort="Ricci, Luisa" uniqKey="Ricci L" first="Luisa" last="Ricci">Luisa Ricci</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: luisa.ricci@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Capelletto, Enrica" sort="Capelletto, Enrica" uniqKey="Capelletto E" first="Enrica" last="Capelletto">Enrica Capelletto</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano, Italy. Electronic address: enrica.capelletto@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pradotto, Monica" sort="Pradotto, Monica" uniqKey="Pradotto M" first="Monica" last="Pradotto">Monica Pradotto</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano, Italy. Electronic address: monica.pradotto@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Napoli, Francesca" sort="Napoli, Francesca" uniqKey="Napoli F" first="Francesca" last="Napoli">Francesca Napoli</name>
<affiliation wicri:level="1"><nlm:affiliation>Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Regione Gonzole 10, 10043, Orbassano, Italy. Electronic address: francesca.napoli@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Pathology Unit, Department of Oncology at San Luigi Hospital, University of Torino, Regione Gonzole 10, 10043, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Di Maio, Massimo" sort="Di Maio, Massimo" uniqKey="Di Maio M" first="Massimo" last="Di Maio">Massimo Di Maio</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Division, Department of Oncology at Mauriziano Hospital, Largo Filippo Turati 62, 10128, University of Torino, Italy. Electronic address: massimo.dimaio@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Medical Oncology Division, Department of Oncology at Mauriziano Hospital, Largo Filippo Turati 62, 10128, University of Torino</wicri:regionArea>
<wicri:noRegion>University of Torino</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novello, Silvia" sort="Novello, Silvia" uniqKey="Novello S" first="Silvia" last="Novello">Silvia Novello</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano, Italy. Electronic address: silvia.novello@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rubinstein, Menachem" sort="Rubinstein, Menachem" uniqKey="Rubinstein M" first="Menachem" last="Rubinstein">Menachem Rubinstein</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, The Weizmann Institute of Science, Herzl Street 234, 76100, Rehovot, Israel. Electronic address: menachem.rubinstein@weizmann.ac.il.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Molecular Genetics, The Weizmann Institute of Science, Herzl Street 234, 76100, Rehovot</wicri:regionArea>
<wicri:noRegion>Rehovot</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scagliotti, Giorgio V" sort="Scagliotti, Giorgio V" uniqKey="Scagliotti G" first="Giorgio V" last="Scagliotti">Giorgio V. Scagliotti</name>
<affiliation wicri:level="1"><nlm:affiliation>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano, Italy. Electronic address: giorgio.scagliotti@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Thoracic Unit and Medical Oncology Division, Department of Oncology at San Luigi Hospital, Regione Gonzole 10, University of Torino, Orbassano</wicri:regionArea>
<wicri:noRegion>Orbassano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Riganti, Chiara" sort="Riganti, Chiara" uniqKey="Riganti C" first="Chiara" last="Riganti">Chiara Riganti</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy. Electronic address: chiara.riganti@unito.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Lung cancer (Amsterdam, Netherlands)</title>
<idno type="eISSN">1872-8332</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (genetics)</term>
<term>Adaptor Proteins, Signal Transducing (metabolism)</term>
<term>Antineoplastic Agents (therapeutic use)</term>
<term>Apoptosis</term>
<term>CCAAT-Enhancer-Binding Protein-beta (genetics)</term>
<term>CCAAT-Enhancer-Binding Protein-beta (metabolism)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Cisplatin (therapeutic use)</term>
<term>Dendritic Cells (immunology)</term>
<term>Drug Resistance, Neoplasm (genetics)</term>
<term>Humans</term>
<term>Lung Neoplasms (drug therapy)</term>
<term>Lung Neoplasms (genetics)</term>
<term>Lung Neoplasms (mortality)</term>
<term>Lymphocyte Activation</term>
<term>Mesothelioma (drug therapy)</term>
<term>Mesothelioma (genetics)</term>
<term>Mesothelioma (mortality)</term>
<term>Oligopeptides (pharmacology)</term>
<term>Pleural Neoplasms (drug therapy)</term>
<term>Pleural Neoplasms (mortality)</term>
<term>Prognosis</term>
<term>Proteolysis</term>
<term>Survival Analysis</term>
<term>Tumor Cells, Cultured</term>
<term>Ubiquitination</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Analyse de survie</term>
<term>Antinéoplasiques (usage thérapeutique)</term>
<term>Apoptose</term>
<term>Cellules cancéreuses en culture</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cisplatine (usage thérapeutique)</term>
<term>Humains</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Mésothéliome (génétique)</term>
<term>Mésothéliome (mortalité)</term>
<term>Mésothéliome (traitement médicamenteux)</term>
<term>Oligopeptides (pharmacologie)</term>
<term>Pronostic</term>
<term>Protéine bêta de liaison aux séquences stimulatrices de type CCAAT (génétique)</term>
<term>Protéine bêta de liaison aux séquences stimulatrices de type CCAAT (métabolisme)</term>
<term>Protéines adaptatrices de la transduction du signal (génétique)</term>
<term>Protéines adaptatrices de la transduction du signal (métabolisme)</term>
<term>Protéolyse</term>
<term>Résistance aux médicaments antinéoplasiques (génétique)</term>
<term>Tumeurs de la plèvre (mortalité)</term>
<term>Tumeurs de la plèvre (traitement médicamenteux)</term>
<term>Tumeurs du poumon (génétique)</term>
<term>Tumeurs du poumon (mortalité)</term>
<term>Tumeurs du poumon (traitement médicamenteux)</term>
<term>Ubiquitinylation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>CCAAT-Enhancer-Binding Protein-beta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>CCAAT-Enhancer-Binding Protein-beta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oligopeptides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Cisplatin</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Neoplasms</term>
<term>Mesothelioma</term>
<term>Pleural Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Resistance, Neoplasm</term>
<term>Lung Neoplasms</term>
<term>Mesothelioma</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mésothéliome</term>
<term>Protéine bêta de liaison aux séquences stimulatrices de type CCAAT</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules dendritiques</term>
<term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
<term>Dendritic Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Lung Neoplasms</term>
<term>Mesothelioma</term>
<term>Pleural Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Mésothéliome</term>
<term>Tumeurs de la plèvre</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine bêta de liaison aux séquences stimulatrices de type CCAAT</term>
<term>Protéines adaptatrices de la transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oligopeptides</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mésothéliome</term>
<term>Tumeurs de la plèvre</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Cisplatine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term>
<term>Humans</term>
<term>Lymphocyte Activation</term>
<term>Prognosis</term>
<term>Proteolysis</term>
<term>Survival Analysis</term>
<term>Tumor Cells, Cultured</term>
<term>Ubiquitination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Analyse de survie</term>
<term>Apoptose</term>
<term>Cellules cancéreuses en culture</term>
<term>Humains</term>
<term>Pronostic</term>
<term>Protéolyse</term>
<term>Ubiquitinylation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cisplatin-based chemotherapy is moderately active in malignant pleural mesothelioma (MPM) due to intrinsic drug resistance and to low immunogenicity of MPM cells. CAAT/enhancer binding protein (C/EBP)-β LIP is a pro-apoptotic and chemosensitizing transcription factor activated in response to endoplasmic reticulum (ER) stress.</div>
</front>
</TEI>
<affiliations><list><country><li>Israël</li>
<li>Italie</li>
</country>
<region><li>Piémont</li>
</region>
<settlement><li>Turin</li>
</settlement>
</list>
<tree><country name="Italie"><region name="Piémont"><name sortKey="Kopecka, Joanna" sort="Kopecka, Joanna" uniqKey="Kopecka J" first="Joanna" last="Kopecka">Joanna Kopecka</name>
</region>
<name sortKey="Ananthanarayanan, Preeta" sort="Ananthanarayanan, Preeta" uniqKey="Ananthanarayanan P" first="Preeta" last="Ananthanarayanan">Preeta Ananthanarayanan</name>
<name sortKey="Capelletto, Enrica" sort="Capelletto, Enrica" uniqKey="Capelletto E" first="Enrica" last="Capelletto">Enrica Capelletto</name>
<name sortKey="Di Maio, Massimo" sort="Di Maio, Massimo" uniqKey="Di Maio M" first="Massimo" last="Di Maio">Massimo Di Maio</name>
<name sortKey="Grosso, Federica" sort="Grosso, Federica" uniqKey="Grosso F" first="Federica" last="Grosso">Federica Grosso</name>
<name sortKey="Libener, Roberta" sort="Libener, Roberta" uniqKey="Libener R" first="Roberta" last="Libener">Roberta Libener</name>
<name sortKey="Milosevic, Vladan" sort="Milosevic, Vladan" uniqKey="Milosevic V" first="Vladan" last="Milosevic">Vladan Milosevic</name>
<name sortKey="Napoli, Francesca" sort="Napoli, Francesca" uniqKey="Napoli F" first="Francesca" last="Napoli">Francesca Napoli</name>
<name sortKey="Novello, Silvia" sort="Novello, Silvia" uniqKey="Novello S" first="Silvia" last="Novello">Silvia Novello</name>
<name sortKey="Orecchia, Sara" sort="Orecchia, Sara" uniqKey="Orecchia S" first="Sara" last="Orecchia">Sara Orecchia</name>
<name sortKey="Pradotto, Monica" sort="Pradotto, Monica" uniqKey="Pradotto M" first="Monica" last="Pradotto">Monica Pradotto</name>
<name sortKey="Ricci, Luisa" sort="Ricci, Luisa" uniqKey="Ricci L" first="Luisa" last="Ricci">Luisa Ricci</name>
<name sortKey="Riganti, Chiara" sort="Riganti, Chiara" uniqKey="Riganti C" first="Chiara" last="Riganti">Chiara Riganti</name>
<name sortKey="Righi, Luisella" sort="Righi, Luisella" uniqKey="Righi L" first="Luisella" last="Righi">Luisella Righi</name>
<name sortKey="Salaroglio, Iris C" sort="Salaroglio, Iris C" uniqKey="Salaroglio I" first="Iris C" last="Salaroglio">Iris C. Salaroglio</name>
<name sortKey="Scagliotti, Giorgio V" sort="Scagliotti, Giorgio V" uniqKey="Scagliotti G" first="Giorgio V" last="Scagliotti">Giorgio V. Scagliotti</name>
</country>
<country name="Israël"><noRegion><name sortKey="Rubinstein, Menachem" sort="Rubinstein, Menachem" uniqKey="Rubinstein M" first="Menachem" last="Rubinstein">Menachem Rubinstein</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C26 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C26 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29748013
   |texte=   Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29748013" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.